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Insufficient testing No data to show they are safe or effective: Most of these substances are not clinically tested on humans, and none of them have undergone the extensive trials required to gain FDA approval as a medicine

Boehringer Ingelheim, the manufacturer, has advanced survodutide into Phase 3 trials for both obesity and metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH)

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Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity